CrimeTide: What's Rising?

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COLUMBIA FILM NOIR // tribute video

A tribute to the film noir of Columbia Pictures. 1945 to 1958. Song is “Black Marlin” by Parov Stelar. Featuring the following films: My Name is Julia Ross (1945) Escape in the Fog (1945) Gilda (1946) So Dark the Night (1946) The Lady From Shanghai (1947) Johnny O'Clock (1947) Dead Reckoning (1947) The Dark Past (1948) Shockproof (1949) Tokyo Joe (1949) The Reckless Moment (1949) The Undercover Man (1949) Knock on Any Door (1949) 711 Ocean Drive (1950) Between Midnight and Dawn (1950) In A Lonely Place (1950) The Mob (1951) The Sniper (1952) The Big Heat (1953) Human Desire (1954) Pushover (1954) Drive A Crooked Road (1954) Tight Spot (1955) 5 Against the House (1955) Nightfall (1956) The Harder They Fall (1956) The Garment Jungle (1957) The Burglar (1957) The Lineup (1958) Murder By Contract (1958) #filmnoir #parovstelar #tribute

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Montgomery Bus Boycott (1955-56)

Via: https://blackpast.org

The Montgomery Bus Boycott in Montgomery, Alabama, was a crucial event in the 20th-century Civil Rights Movement. On the evening of December 1, 1955, Rosa Parks, a Montgomery seamstress on her way home from work, refused to give up her seat on the bus for a white man and was subsequently arrested. The President of the local chapter of the National Association for the Advancement of Colored People (NAACP), E.D. Nixon, used the arrest to launch a bus boycott to fight the city’s segregated bus policy. Together with Jo Ann Robinson of the Women’s Political Council and other black leaders, Nixon set plans for the boycott. The idea of the boycott had been floating around for months. Both Nixon and Robinson were waiting for a test case to challenge the segregated bus policy in Court. They knew they would have strong support from black women, who made up the majority of bus users. The only thing missing was a good test candidate, and respectable, middle-class Rosa Parks seemed perfect for the role. On Friday, December 2, Robinson created a flyer which she distributed to black families around Montgomery. The flyer told of the arrest of Parks and mentioned that 75% of the bus […]

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Steve Earle witnesses the execution of a friend

Via: http://www.theguardian.com

Country musician Steve Earle corresponded with convicted murderer Jonathan Wayne Nobles for 10 years, but met him for the first time just a month before he was killed by lethal injection. Here he records his harrowing daily visits to prison, and the night he witnessed the execution of his friend.

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On the Anniversary of the Hanging of Ruth Ellis

Via: https://www.wedossett.com

Wendy Dossett67 years ago, on July 13th 1955, Ruth Ellis (aged 28) was hanged. She was the last woman in the United Kingdom to be killed by the State as punishment for a capital crime. She’d shot her lover, David Blakely, outside a pub, in what was ruled to have been a premeditated murder. Another male associate, Desmond Cussen, had given her the gun and driven her to the scene. In her trial, Ellis was frank and direct about what she had done, and she considered her punishment just and due. Toda

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Oliver Magnum - Sister Cybele (1989)

Via: https://youtube.com

From the album “Oliver Magnum” (1989) All material uploaded to the channel is for entertainment purposes only. All rights and credits go to the owners of the audio recordings, with no intention of copyright infringement. The channel does not monetize or add the ads on the videos. This is done through YouTube and the license holders, all proceeds goes to the rightful owners.

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Charles Diggs (1922-1998)

Via: https://blackpast.org

Charles Diggs was born in Detroit, Michigan, in 1922. His father was Charles Coles Diggs, and his mother was Mayme Jones Diggs. Young Diggs had an upper-middle-class background; his father, a prominent mortician and real estate developer, served in the Michigan State Senate. Diggs eventually took over the family business and followed his father into politics. As a high school student, Diggs was a star debater. He attended the University of Michigan and then Fisk University in Nashville, Tennessee. In 1943, he was drafted into the Army Air Corps and stationed at Tuskegee Airfield. The war ended without Diggs ever seeing combat. He returned to Detroit and graduated from Wayne State University in 1946. In 1950, Diggs was elected to the Michigan State Senate. Four years later, he became Michigan’s first Black Congressman when in 1954, he was elected to represent Michigan’s Thirteenth Congressional District, then a predominately white area. He would represent the district for the next 26 years. As a member of Congress in the 1950s, Diggs worked to promote the civil rights movement emerging across the nation. He was the only Congressman to attend the Mississippi trial of the men accused of murdering Emmett Till. He was especially interested […]

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Mike Tyson WON'T Back Down From His Trump Support!

Via: https://youtube.com

NOTE: Fair use applies when using copyrighted material for purposes such as commentary, criticism, news reporting, teaching, scholarship, or research—which is exactly how I use content in my videos. I typically highlight moments, share opinions, or point things out. These videos are for entertainment and informational purposes only and are not meant to offend anyone. If you own any content featured here and would like it removed, feel free to contact me directly.

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Via: https://www.nicovideo.jp

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Jean-Baptiste-Camille Corot (1796 - 1875) | National Gallery, London

Via: https://www.nationalgallery.org.uk

Born in Paris on 17 July 1796, Corot was the son of a cloth merchant and a milliner. After an education at the Collège de Rouen and two abortive apprenticeships with drapers, he was given the financial freedom at the age of 26 to devote himself to painting. He first studied with the landscapist Achille Etna Michallon, and after his death with Jean-Victor Bertin (around 1767 to 1842), both pupils of Pierre-Henri de Valenciennes.

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Young Sherlock Holmes (1985)

Via: https://letterboxd.com

Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.

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(1793) Fugitive Slave Act

Via: https://blackpast.org

Chap. VII.—An Act respecting fugitives from justice, and persons escaping from the service of their masters. Section 1. Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled, That whenever the executive authority of any state in the Union, or of either of the territories northwest or south of the river Ohio, shall demand any person as a fugitive from justice, of the executive authority of any such state or territory to which such person shall have fled, and shall moreover produce the copy of an indictment found, or an affidavit made before a magistrate of any state or territory as aforesaid, charging the person so demanded, with having committed treason, felony or other crime, certified as authentic by the governor or chief magistrate of the state or territory from whence the person so charged fled, it shall be the duty of the executive authority of the state or territory to which such person shall have fled, to cause him or her to be arrested and secured, and notice of the arrest to be given to the executive authority making such demand, or to the agent of such authority appointed to receive […]

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Dando vida a heroínas atormentadas, Mercè Rodoreda (1908-1983)

Via: https://www.mujeresenlahistoria.com

Más de diez novelas, recopilaciones de cuentos exquisitos, poemas, artículos periodísticos, entrevistas, una ingente producción literaria ha convertido a Mercè Rodoreda en una de las escritoras más importante y la más influyente de las letras catalanas de los últimos tiempos. Recibió más de quince premios y su obra fue traducida a cuarenta idiomas.

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NEW ???? The Horse - Cliff Nobles & Co. {Stereo} 1968

Via: https://youtube.com

1968......#2 U.S. Billboard Hot 100, #2 U.S. Cash Box Top 100, #7 Canada Original video edited and remastered with HQ stereo sound. "The Horse" is an instrumental song by Cliff Nobles and Company. It was released as the B-side of the single "Love Is All Right" and is simply an instrumental version of that song. Although Nobles is the title artist, he does not personally perform on the track. The song was simply "Love Is All Right" without his vocal track. The horn section which is featured eventually became the group MFSB. Mike Terry played the baritone saxophone on this recording. The track itself features a simple, unvarying rhythmic line played by different instruments, finished off each time around by a melodic, heralding horn section line. According to Bobby Eli, a guitarist on the session, the instrumental track was the result of his jamming in the studio with guitarist Norman Harris, bassist Ronnie Baker, and drummer Earl Young (later to become the first MFSB rhythm section and the core of the group the Trammps). The jam was then "tweaked" by arranger Bobby Martin and recording studio owner and engineer Frank Virtue. Neither Cliff Nobles nor producer Jesse James was present for the session. It peaked at number 2 on both the US Billboard Hot 100 chart (in June 1968) and the US Billboard R&B chart. In Canada the song reached number 7. The song sold a million copies within three months of release, and attained the gold record award from the Recording Industry Association of America in August 1968.

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Flying Duck Theory (Demo 1977)

Via: https://youtube.com

Provided to YouTube by The Orchard Enterprises Flying Duck Theory (Demo 1977) · The Vibrators · John Ellis The Demos 1976-1978 ℗ 2021 Cleopatra Records Released on: 2021-12-10 Music Publisher: Mechanical Copyright Protection Society Ltd. Auto-generated by YouTube.

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Impresionante perímetro de seguridad en Valladolid para que no hubiera abucheos a Sánc-HEZ

Via: https://eldiestro.tv

Lo de este psicópata es impresionante.

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Don't Compare Me With Stark! | Marvel's Avengers: Age of Ultron (2015)

Via: https://youtube.com

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To Kill A Mockingbird (1962) Official Trailer

Via: https://youtube.com

Scout Finch (Mary Badham), 6,and her older brother, Jem (Phillip Alford), live in sleepy Maycomb, Ala., spending much of their time with their friend Dill (John Megna) and spying on their reclusive and mysterious neighbor, Boo Radley (Robert Duvall). When Atticus (Gregory Peck), their widowed father and a respected lawyer, defends a black man named Tom Robinson (Brock Peters) against fabricated rape charges, the trial and tangent events expose the children to evils of racism and stereotyping.

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心はどこへ消えた？

Via: https://www.audible.co.jp

『居るのはつらいよ』で第19回大佛次郎論壇賞受賞、紀伊国屋じんぶん大賞をW受賞した気鋭の著者が「心とは何か」という直球の問いに迫る、渾身のエッセイ。 ©東畑開人 (P)2021 Bungeishunju Ltd....

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A Wonderful Lie | Official Trailer | Thriller Movie 2025

Via: https://youtube.com

When bestselling author Rebecca Sinclair goes missing, a tangled web of secrets, betrayal, and manipulation unfolds. As her husband, best friend, and sister scramble to control the narrative, investigators begin to suspect that the truth is far more twisted than anyone imagined. Was it a kidnapping… or something far more calculated? This gripping psychological drama will keep you questioning who to trust until the very last frame. ???? Starring: Renatta Nikole, Sherree Patton-Grantham, Kendra Carter, Ronza Bee ???? Written & Directed by: Bobby & Renee Peoples ???? Don’t forget to like, share, and subscribe for more intense indie dramas from The Peoples Network! #AWonderfulLie #PsychologicalDrama #TPN #IndieFilm #WatchOnTubi #ThrillerMovie #TPNFilms

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PhD Opportunities » Babraham Institute

Via: https://www.babraham.ac.uk

PhD opportunities at the Institute are typically open for applications between October and December of the year prior to the start of your studies. Please find below the full list of projects on offer for the 2027 intake at the Babraham Institute, follow the specific instructions on how to apply for each project in the advertisement, as the requirements of each differ. Please do not send your application directly to the Institute, you must submit your applications through the University of Cambridge Admission Portal. Please see 'What happens next?' For personal stories and tips on PhD studies from some of our researchers and to get a clearer view of the different roles available at the Institute, hear from our students in this video, read blogs by our students or visit our careers video page. Here is the full list of PhD studentships on offer for the 2027 intake at the Babraham Institute. The applications deadline for all PhD studentships: 8th December 2027 Please note interviews will be held the week commencing 18th January 2027 Bioscience South Cambridge doctoral training Partnership (BioSCaPe) Bioscience South Cambridge doctoral training Partnership (BioSCaPe) is a transformative PhD programme designed to create the bioscience leaders of tomorrow. Based in the heart of the world-leading Cambridgeshire bioscience cluster, BioSCaPe offers an unparalleled opportunity to combine cutting-edge research with entrepreneurial and leadership skills. BioSCaPe is a partnership between four world-leading research organisations; the Babraham Institute, Wellcome Sanger Institute, MRC Laboratory of Molecular Biology, and the University of Cambridge in collaboration with major industry partners including AstraZeneca, Illumina, Alloy Therapeutics, and others, alongside the Babraham Research Campus and its network of bioscience companies. Starting October 2027, 4-year Research Studentships will be available, leading to a University of Cambridge PhD degree, in the laboratories of Dr Jon Housley, Dr Teresa Rayon and Dr Arianne Richard at the Babraham Institute. Details of the Babraham Institute’s interactive scientific programmes can be found on www.babraham.ac.uk. As a student at the Institute, you will have access to all of the outstanding science facilities, each one providing specialist equipment and expertise to support key research techniques and technologies. Project Title: The dark side of DNA Project Outline We think of DNA as a stable information source compartmentalised to the nucleus and mitochondria. When DNA enters the cytosol, it is recognised as a pathogen-associated molecular pattern by immune mechanisms that trigger inflammatory responses. However, a spectrum of diseases arise from mutations that increase formation or limit degradation of cytosolic DNA, even in the absence of infection. So, endogenous DNA must enter cytosol under normal conditions, but where this DNA comes from, why it is made and how it enters the cytosol remains largely mysterious. We have found that proliferating cells produce copious DNA that is exported from the nucleus, indicating that excess DNA synthesis is a normal, unavoidable part of nuclear metabolism. Many diseases including progerias (accelerated ageing conditions) are caused by mutations in DNA repair genes, while cytosolic chromatin is a characteristic feature of cellular senescence, raising questions as to whether DNA escaping the nucleus is a common factor in ageing and disease. We hypothesise that DNA egress from the nucleus is a major driver of disease and ageing, and is accentuated by mutations affecting DNA repair. This PhD project will use bespoke DNA sequencing methods to quantify and profile populations of cytosolic DNA, investigate formation mechanisms, and reveal mechanistic links to ageing and disease. Project Aims Refine methods to sequence cytosolic and secreted DNA in proliferating and quiescent cells carrying selected pathogenic mutations (WRN, ATM, ERCC1, RNASEH2, plus others that may be found to be relevant), then use DDR drugs to probe the DNA processing pathways generating this DNA. Apply these sequencing methods to tissue from young and old mice, to ask where cytosolic DNA accumulates and how this affects measured hallmarks of ageing. Once established, these methods could be applied to other tissues and/or clinical samples if available. Determine how different pathways of nuclear DNA egress lead to different immunogenic species, asking what is exported, where it goes, how it is processed and which immune receptors can be activated. This project will involve a mixture of wet and dry lab techniques. The successful candidate will generate sequencing libraries and optimise methods, then perform their own bioinformatic analysis. When implementing novel sequencing pathways, it is critical that the bioinformatics is performed with a thorough understanding of the method. All necessary training will be provided but a keen interest in bioinformatics would be an advantage. The project will be carried out within the Epigenetics Programme at the Babraham Institute, offering an outstanding interdisciplinary environment with expertise spanning epigenetics, development, signalling and ageing. Principal Supervisor Dr Jon Housley Email address: jon.houseley@babraham.ac.uk Fully funded BioSCaPe iDLA Studentship URL link to personal profile page or website: Jon Houseley » Babraham Institute Further details about the BioSCaPe iDLA including how to apply can be found here Project Title: Cross-Species determinants of stress susceptibility in PSC-derived Neural Progenitors and Spinal Motor Neurons Life unfolds at remarkably different speeds across species, yet the molecular mechanisms that regulate developmental tempo remain poorly understood. A central unresolved question in developmental and evolutionary biology is how timing is controlled across species, with major implications for stem cell biology, regenerative medicine, and disease modelling. Emerging evidence suggests that stress responses, which vary across species and influence embryonic development, may act not only as protective mechanisms but also as active regulators of developmental timing and cellular maturation. However, it remains unknown how stress-response dynamics are integrated with developmental programs during neuronal differentiation, and how their dysregulation contributes to neurodevelopmental and neurodegenerative disease, including amyotrophic lateral sclerosis (ALS). Motor neurons provide a powerful and clinically relevant system to address this question due to their high metabolic demand, intrinsic stress sensitivity, and selective vulnerability in ALS and related disorders. Pluripotent stem cell (PSC)-derived motor neurons are widely used for disease modelling and neurotoxicity screening, but show substantial variability across species and developmental states. Whether this reflects developmental maturity, species-specific biology, or intrinsic differences in stress responsiveness remains unresolved. Building on previous work demonstrating conserved differences in motor neuron developmental tempo between mouse and human (Rayon et al., Science, 2020; Nakanoh, Stamataki et al., bioRxiv, 2025), this four-year industrial PhD project, in partnership with Axol, will establish a cross-species and disease-relevant stem cell platform to define how developmental state and species identity shape neuronal stress susceptibility, with direct relevance to ALS. Using pluripotent stem cell (PSC)-derived neural progenitor cells (NPCs) and spinal motor neurons (MNs) from multiple mammalian species, the student will investigate how stress responses emerge during neuronal differentiation and how they relate to developmental tempo, maturation, and disease-relevant vulnerability. Project aims: Develop a harmonised cross-species stem cell platform by generating spinal motor neurons from multiple mammalian PSC lines, including human and non-human primates. Define how stress susceptibility changes during neuronal development by comparing neural progenitor cells and motor neurons. Identify molecular signatures of stress resilience and vulnerability using comparative proteomic profiling. Determine how stress-response pathways influence developmental timing and neuronal maturation through targeted functional perturbations. Overall, this four-year industrial PhD project will uncover how stress biology is integrated into neural developmental programs across species, and how this integration shapes motor neuron maturation, resilience, and vulnerability in ALS. Research environment The Rayon Lab investigates the molecular and metabolic mechanisms that regulate biological timing, developmental tempo, and lifespan across species. The group combines stem cell and embryo models with quantitative experimental and computational approaches to understand how developmental processes evolve and are regulated. The project is based at the Babraham Institute and will be conducted in close collaboration with Axol, providing exposure to both academic and industrial research environments. The student will have access to state-of-the-art facilities and expertise in stem cell biology, developmental biology, imaging, genomics, proteomics, and computational analysis. Candidate profile We welcome applications from motivated students with interests in developmental biology, stem cells, neuroscience, evolution, or quantitative biology. Previous experience in cell culture, molecular biology, bioinformatics, or programming would be advantageous but is not essential, as full training will be provided. This project offers a unique opportunity to address a fundamental biological question while developing innovative stem cell technologies with direct relevance to disease modelling, drug discovery, neurotoxicity testing, and the development of more predictive preclinical models. Informal enquiries, including a brief statement of motivation, are encouraged. Please contact Teresa Rayon. Principal Supervisor Dr Teresa Rayon Email address: Teresa.rayon@babraham.ac.uk Fully funded BioSCaPe iDLA Studentship URL link to personal profile page or website: Teresa Rayon | Babraham Institute Further details about the BioSCaPe iDLA including how to apply can be found here Project Title: T cell signalling in fibrotic feedback loops Fibrosis is a pathological feature of many chronic inflammatory diseases, characterized by extracellular matrix (ECM) dysregulation, connective tissue accumulation, and complex immune-stromal feedback loops. Studies of cytotoxic (CD8) T cells in fibrotic tissues have revealed altered phenotypes and suppressed function, and there is evidence to suggest that while functional CD8 T cells can prevent or resolve fibrosis, their dysregulation in the fibrotic environment contributes to tissue decline. We are interested in the signalling mechanisms underlying the fibrosis-associated T cell state, specifically in the context of endometrial fibrosis. Endometriosis is a debilitating condition affecting 10% of women of child-bearing age that has no cure. The fibrotic tissue environment is a key feature of endometriosis and is characterized by particularly high levels of TGF and dysregulated IL-15, which are known to regulate differentiation state, cytotoxic function, and both antigen-driven and antigen-independent activation of CD8 T cells. This project will examine the endometriosis-associated cytokine milieu, signalling of these cytokines in CD8 T cells, and the molecular mechanisms connecting this signalling to altered differentiation state and function. The project is a collaboration between the Richard Lab at the Babraham Institute and Cyclana Bio. The Richard Lab studies how T cell activity is altered by variations in antigen binding and the microenvironment 1-4. Cyclana Bio is a biotech company with a mission to develop disease-reversing therapeutics to cure endometriosis. Cyclana also has strong academic roots in ECM biology 5. The project will leverage the T cell expertise and experimental platforms from the Richard lab alongside endometriosis expertise and novel 3D tissue models developed by Cyclana Bio to examine the consequences of fibrosis-associated cytokine signalling in CD8 T cells. We are particularly focused on gaining mechanistic insight by identifying signalling, epigenetic, transcriptomic, and/or translational mediators of differentiation and functional effects. The student will have the opportunity to work in both industry and academic settings. They will be involved in all aspects of project planning, experimentation and analysis, with support from other team members. At Cyclana, the student will experience a small biotech working environment, contribute to work with clinical samples, and learn to use 3D tissue models with advanced tissue culture and imaging techniques. At the Babraham Institute, the student will benefit from a highly collaborative institute with collective expertise in Immunology, Signalling, and Epigenetics, and will have the opportunity learn a variety of immunological and genomic techniques including functional secretion and cytotoxicity assays, migration assays, signalling measurements, flow cytometry, single-cell and bulk transcriptomics, proteomics, CUT&Tag, CRISPR/Cas9 genome editing, and bioinformatic and statistical analysis of generated data. The student will share their research through publications and presentations at internal meetings and external conferences in both academic and industrial settings. References Panova V, et al. T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo, inversely regulating cell division and interferon response (2026) BioRxiv. Richard AC. Divide and conquer: phenotypic and temporal heterogeneity within CD8+ T cell responses. (2022) Front Immunol, 13:949423. Ma CY, et al. Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling. (2020) Elife, 9:e53948. Richard AC, et al. T cell cytolytic capacity is independent of initial stimulation strength. (2018) Nat Immunol, 19(8):849–58. Mui BWH, Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration. Science (2026) 392(6794):eady3136. Principal Supervisor Dr Arianne Richard Email address: Arianne.Richard@babraham.ac.uk Fully funded BioSCaPe iDLA Studentship URL link to personal profile page or website: Arianne Richard | Babraham Institute Further details about the BioSCaPe iDLA including how to apply can be found here Bioscience South Cambridge doctoral training Partnership (BioSCaPe) The Cambridge Biosciences Doctoral Training Partnership (DTP), funded by the Doctoral Landscape Awards under UKRI brings together four world-leading research institutions — the University of Cambridge, the Babraham Institute, the National Institute of Agricultural Botany (NIAB), and the Wellcome Sanger Institute — in partnership with UK Research and Innovation (BBSRC). It aims to train the next generation of Bioscience leaders by providing research projects in our world leading groups, complemented by a training and cohort-building programme to develop their professional and transferable skills, and opportunities to work in diverse professional environments. This programme provides training opportunities across the scientific areas encompassed by the Biotechnology and Biological Sciences Research Council (BBSRC) strategic research priorities: Understanding the rules of life Transformative technologies Bioscience for sustainable agriculture and food Bioscience for renewable resources and clean growth Bioscience for an integrated understanding of health. Further information about the Cambridge Biosciences DTP PhD Programme can be found here. Starting October 2027, a 4-year Targeted Research Studentship will be available, leading to a University of Cambridge PhD degree, in the laboratory of Dr Philipp Voigt at the Babraham Institute. Project title: Poised Chromatin and the Epigenetic Control of Development Project outline How cells switch genes on and off at the right time is fundamental to development. In embryonic stem cells, many genes whose expression is required later in development are kept in a ""poised"" state, ready to be activated during cell lineage commitment. This poised state is controlled by chromatin, where specific histone marks create regulatory environments that either promote or repress gene expression. However, the mechanisms that allow these poised genes to respond rapidly to developmental signals remain poorly understood. Our recent work has identified several previously uncharacterised histone acetylation marks at these poised genomic regions, known as bivalent chromatin domains. This project will investigate how these acetylation marks control gene expression during cell differentiation and development. The student will test whether the acetylation marks recruit specific ""reader"" proteins that help activate developmental genes or influence gene repression pathways. Using embryonic stem cell models, the project will examine where these proteins bind across the genome, how they are recruited to chromatin, and how they affect gene activity as cells differentiate. The student will also identify additional factors that work together with these proteins to regulate developmental gene expression. The project combines molecular biology, genomics, biochemistry and stem cell biology. Training will include genome-wide approaches such as ChIP-seq and RNA-seq, bioinformatic data analysis, CRISPR-based genome editing, stem cell differentiation, protein degradation systems, chromatin biochemistry and proteomics. The work will provide broad training in epigenetics and gene regulation while addressing a fundamental question in developmental biology. The project will be carried out within the Epigenetics Programme at the Babraham Institute, offering an outstanding interdisciplinary environment with expertise spanning epigenetics, development, signalling and ageing. Principal Supervisor Dr Philipp Voigt Email address: philipp.voigt@babraham.ac.uk Fully funded Cambridge Biosciences Doctoral Training Partnership (DTP) Targeted Studentship (Project Reference: TRG27-BAB-PV1) URL link to personal profile page or website: Philipp Voigt | Babraham Institute Further details about the Cambridge Biosciences Doctoral Training Partnership (DTP) including how to apply can be found here. PhD in Biological Science (Babraham Institute) PhD in Biological Science (Babraham Institute). The Babraham Institute is a world-leader in fundamental biological research investigating the systems that underpin development and healthy ageing. We support full-time PhD students on three-to-four-year studentships and the projects mentioned below are open for applications. Please note, these studentships are competition funded studentships (unfunded) and so you will need to apply for your own funding. Possible sources of funding include the University of Cambridge-wide funding competitions, such as the Gates Cambridge Trust and Cambridge Trust (please visit the University of Cambridge Funding Search webpage). Please ensure you check the postgraduate funding competition box when applying. Project Title: Spatial Control of Wnt–ERK Signalling by Glypican-Dependent Ligand Dispersal in Development and Disease Glypicans are a family of heparan sulfate proteoglycans that regulate extracellular signalling environments during development. Human genetics highlights the importance of this regulation: loss-of-function mutations in GPC6 cause omodysplasia, a rare skeletal dysplasia characterised by impaired growth and developmental defects. More recently, genetic studies have implicated glypicans in neurological disease, with emerging links to disorders including schizophrenia and Parkinson’s disease. Despite these associations, the molecular mechanisms by which glypicans shape signalling outputs in different tissues remain poorly understood. Recent work has identified a conserved role for GPC6 in controlling the extracellular distribution of Wnt ligands. Disruption of this process collapses Wnt gradients and leads to spatially restricted signalling, suggesting that glypicans regulate not only the range but also the intensity of morphogen signalling. We have found that loss of GPC6 function leads to hyperactivation of ERK signalling, through dysregulated non-canonical Wnt pathway activity. This suggests that extracellular control of Wnt ligand distribution can directly influence intracellular signalling output, but the molecular mechanisms linking these processes remain unclear. This project will investigate how glypican-dependent regulation of Wnt signalling is coupled to ERK activation, with a particular focus on identifying the signalling cascade linking extracellular ligand organisation to downstream pathway output. Particular emphasis will be placed on the role of small GTPase-mediated signalling in integrating spatially restricted Wnt signals and modulating intracellular pathway activity. The project will primarily focus on the nervous system, where non-canonical Wnt signalling plays key roles in regulating cell polarity, migration, neurite outgrowth, and neuronal specification. These processes are essential for the formation and maintenance of neural circuits and have been increasingly implicated in neurodevelopmental and neurodegenerative disorders. The student will investigate whether loss of GPC6 leads to dysregulated Wnt–ERK signalling in the developing mouse brain, with a particular focus on dopaminergic neuron specification and patterning. To explore relevance to human disease, the project will use induced pluripotent stem cell (iPSC)-derived neurons and astrocytes to test whether similar signalling mechanisms operate in human cells. A key aspect of the project will be to define the downstream consequences of dysregulated Wnt–ERK signalling in neural cells. Non-canonical Wnt signalling, including Wnt5a-dependent pathways, plays an important role in neuronal maturation, regulating cytoskeletal organisation, neurite development, and synaptic connectivity—processes that intersect with ERK-dependent signalling networks. The student will investigate how perturbation of GPC6 alters these downstream responses, with a particular focus on identifying signalling targets and cellular behaviours that are Wnt-Erk regulated. Understanding these outputs will be important not only for defining core biological mechanisms, but also for improving in vitro models of neuronal differentiation and maturation, ensuring that iPSC-derived neurons faithfully recapitulate relevant developmental signalling states. Together, this project will define how extracellular regulation of morphogen signalling is translated into intracellular pathway activation, providing new mechanistic insight into how disruption of signalling architecture can contribute to developmental defects and neurological disease. This project will be undertaken with BitBio. Principal Supervisor Dr Ian McGough Email address: Ian.McGough@babraham.ac.uk Competition funded studentship (unfunded) – you will need to apply for your own funding. Possible sources of funding include the University of Cambridge-wide funding competitions, such as the Gates Cambridge Trust and Cambridge Trust (please visit the University of Cambridge Funding Search webpage). Please ensure you check the postgraduate funding competition box when applying. URL link to personal profile page or website: Ian McGough | Babraham Institute Project Title: Fantastic proteins and where to find them: exploring the biology of histones outside the nucleus Histone proteins package DNA within the confines of the nucleus in a macromolecular structure called chromatin. They additionally modulate the accessibility of DNA to gene and epigenetic regulators through the chemical modifications they carry (post-translational modifications, PTMs). Beyond their fundamental functions in genome packaging and regulation, histones have a life outside the nucleus: they are potent antimicrobial agents and the externalization of chromatin as an immune defense mechanism is a process that is as ancient and widespread across three of life as chromatin itself 1,2. We have discovered that histones are externalized in previously unappreciated contexts, beyond immune cells and immune defense. This discovery opens a new frontier in cell biology and the study of chromatin. Our lab focusses on the study of histone citrullination3, the only known PTM specifically associated with histone externalization – indeed, extracellular histones are practically impossible to detect with confidence using current analytical methods, but citrullination can be used as a beacon that helps us locate this particular histone pool. Using tools and systems we have developed for the study of citrullination4-8, we are well placed to investigate the biology of extracellular histones in a variety of physiological or pathophysiological contexts. This project will investigate the biology of histone externalization during tissue development, homeostasis and ageing. The work will be organized in three specific aims, which will address the following questions: What is the mechanism of tissue externalization? We will employ cell biological and biochemical analyses, coupled with powerful imaging technologies, to understand the pathways through which citrullination is activated and histones are externalized. What are the consequences of extracellular histone sensing by neighbouring cells? We will employ protein biochemistry and genome sequencing technologies to understand the signalling, transcriptomic and epigenetic changes undergone by cells that come in contact with extracellular histones. Our findings so far indicate that these cell responses differ drastically depending the age of the recipient cells, thus this aim will allow us to investigate how cell resilience is eroded during ageing. Which molecular pathways mediate the responses to extracellular histone? Using the readouts identified in Aim 2 and high-resolution proteomic analyses, we will aim to identify the molecules that mediate extracellular histone responses. Through this research we will investigate a novel type of cell communication and its roles in mammalian development and ageing. The student who undertakes this work will obtain training in cell and developmental biology, protein biochemistry, genomics, proteomics, state-of-the-art imaging and bioinformatic analyses. Although we have a particular interest in developmental biology, tissue stem cells and ageing, the student joining our lab will have the opportunity to incorporate their own interests and inform the direction of their project. References: Sollberger G., Tilley D.O., Zychlinsky A. (2018). Neutrophil Extracellular Traps: The biology of chromatin externalization. Dev Cell 44(5):542-553. doi: 10.1016/j.devcel.2018.01.019. PMID: 29533770. Grinat J., Shriever, N.P., Christophorou M.A. (2024). Fantastic proteins and where to find them – histones, in the nucleus and beyond. J Cell Sci, 137(24):jcs262071. doi: 10.1242/jcs.262071. PMID: 39704565. Christophorou M.A. (2022). The virtues and vices of protein citrullination. R Soc Open Sci. 9(6):220125. doi: 10.1098/rsos.220125. PMID: 35706669. Christophorou, M.A.*, Castelo-Branco, G.*, Halley-Stott, R., Slade Oliveira C., Loos R., Radzisheuskaya A., Mowen K., Bertone P., SIlva J.C.R., Zernicka-Goetz M., Nielsen M.L., Gurdon J.B., Kouzarides T. (2014). Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature 507:104–108. doi: 10.1038/nature12942. PMID: 24463520. Cummings T.F.M., Gori K., Sanchez-Pulido L., Gavriilidis G., Moi D., Wilson A.R., Murchison E., Dessimoz C., Ponting C.P., Christophorou M.A. (2022). Citrullination Was Introduced into Animals by Horizontal Gene Transfer from Cyanobacteria. Mol Biol Evol. 39(2):msab317. doi: 10.1093/molbev/msab317. PMID: 34730808. Singh A., Khan S., Moore D., Andrews S., Christophorou M.A. (2023). Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci, 378(1890): 20220236. doi: 10.1098/rstb.2022.0236. PMID: 37778387. Bertran M.T.*, Walmsley R.*, Cummings T., Aramburu I.V., Benton D.J., Mora Molina R., Assalaarachchi J., Chasampalioti M., Swanton T., Joshi D., Federico S., Okkenhaug H., Yu L., Oxley D., Walker S., Papayannopoulos V., Suga H., Christophorou M.A.**, Walport L.J.** (2024). A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. Nat Commun. 15(1):9746. doi: 10.1038/s41467-024-53554-1. PMID: 39528459;. Rebak A.S., Hendriks I.A., Elsborg J.D., Buch-Larsen S.C., Nielsen C.H., Terslev L., Kirsch R., Damgaard D., Doncheva N.T., Lennartsson C., Rykær M., Jensen L.J., Christophorou M.A., Nielsen M.L. (2024). A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates. Nat Struct Mol Biol. 31(6):977-995. doi: 10.1038/s41594-024-01214-9. PMID: 38321148. Principal Supervisor Dr Maria Christophorou Email address: Maria.Christophorou@babraham.ac.uk Competition funded studentship (unfunded) – you will need to apply for your own funding. Possible sources of funding include the University of Cambridge-wide funding competitions, such as the Gates Cambridge Trust and Cambridge Trust (please visit the University of Cambridge Funding Search webpage). Please ensure you check the postgraduate funding competition box when applying. URL link to personal profile page or website: Maria Christophorou | Babraham Institute

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Watch Delhi Police Detain A Few Cjp Protesters Hiding Inside Washroom Near Sansad Marg Area

Via: https://www.aninews.in

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Theatr Ardudwy: 'Fraudulent' theatre producer 'misled' community

Via: https://www.bbc.co.uk

Kallum O'Sullivan promised to reinvent Theatr Ardudwy after it closed in 2017 due to safety concerns.

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What Does The Fox Say?! Ylvis - The Fox (official video + lyrics)

Via: https://youtube.com

Ylvis of @TV_NORGE with -The Fox- Don't thank me, thank him^-^ Official Music Video + lyrics #LOL #BestSongEver -------------------------------------------------------------------------------------------------------------------------------- Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. NO COPYRIGHT INTENDED

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Migliori Siti Slot Online AAMS 2026: Top 10 Sicuri in Italia

Via: https://www.ninkasishop.it

Migliori siti slot online AAMS del 2026: confronta i casinò ADM sicuri per bonus, free spin, RTP e prelievi. Scopri la classifica aggiornata e scegli!

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Autistic son handcuffed by police on first day of term at academy

Via: https://www.nottinghampost.com

His mum said he was 'treated like a criminal'

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Dutch Police Revolver (with safety!)

Via: https://youtube.com

This Dutch police revolver is an interesting example of technology being used as an element of police policy and procedure. The Dutch police administration in the late 1800s/early 1900s decided that officers should carry a blank round in the first chamber of their revolvers, a tear gas round in the second chamber, and actual live bullets only in the 3rd-5th chambers. This led to a problem of ensuring that officers were able to easily confidently know which type of ammunition they were firing at any given time - what if a cylinder happened to rotate while being drawn, holstered, or otherwise handled without the officer noticing? He might fire a live round when intended to use a blank, or vice versa. The solution was to add a large manual safety that would lock the cylinder in position, and add large marking to the outside of the first two chambers indicating which was which. Setting aside the wisdom of this sort of progressive cartridge selection, the mechanical adaptation of the police revolvers is an interesting thing to see, and one of a relatively small number of revolvers to have manual safeties.

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GDTC Stock Price, News & Analysis

Via: https://www.stocktitan.net

CytoMed Therapeutics Limited (NASDAQ: GDTC) is a Singapore-based clinical stage biopharmaceutical company developing donor-derived allogeneic cell therapies for cancers.

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Charlie Rouse - Nutty (1988)

Via: https://youtube.com

This rendition of Nutty comes from the 1988 album Epistrophy by Charlie Rouse. « Although he had an extensive career, tenor saxophonist Charlie Rouse is best remembered for his decade (1960-1970) as a member of the Thelonious Monk Quartet. It is only right that the last time that he picked up his horn was for a Monk tribute concert. This historic event, originally released by Landmark and reissued with one extra selection on a 1997 32 Jazz CD, finds Rouse in prime form despite the fact that he had just seven weeks to live (before passing on from lung cancer). The date was special from the start, with producer Orrin Keepnews getting Rouse to say a few words to the audience about his time with Monk. There are renditions of "Nutty" and "Ruby, My Dear" that match Rouse with pianist George Cables, bassist Jeff Chambers and drummer Ralph Penland. » Allmusic (allmusic.com/album/epistrophy-mw0000653863) Quality is MP3 256kbps. I do not own the rights for this music, copyright holders can ask me to remove it. That'd be a loss though.

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Mrs Buică - Trailer cinema

Via: https://youtube.com

Doi Lei Și O Chiflă prezintă un film de Eugene Buică „Mrs. Buică“ montajul Ligia Popescu și Andrei Ioniță imaginea Gene Gamache și Eugene Buică scris, regizat și produs de Eugene Buică Filmul va avea premiera în cinematografe în data de 8 decembrie. Descoperim atmosfera din familia Buică. Aceasta poate să pară agresivă, poate să pară plină de iubire, poate să pară delirantă sau chiar vicioasă, dar cu siguranță are și umor. O producție realizată cu imagini înregistrate timp de 24 de ani, în România și Statele Unite ale Americii Din 8 decembrie 2023 în cinema

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Skids - A Day In Europa

Via: https://youtube.com

Song from The Skids 2nd album, "Days In Europa". From the corner I bled with dismay Sight of my victims It was my judgement day Walking the street So subtle and calm Caught in my pocket Was an Arian psalm And the memory shall linger And the memory shall fall It was a day in Europa My regression recalls Invent the position I attempt to conceal Vice of my nature The intruders can`t steal Model the guilty I blame the blamed Trangressions liable To cover in shame And the stainless shall linger And the guiltless prevail It was the day of our glory My righteousness hails Death the avenger I kill the unworthy goals Chase of their evil Yes, we had control Assist my mission Please don`t refrain Destroy the corruption Don`t take it in vain Oh, hear the singing The churches and the choirs Chanting hail to the mighty Oh, they are not lying Let us hail to mighty, the ritual begins Let us hail to Apollo, the cleanser of sins Let us hail to Europa, she always wins And the memory shall linger And the memory shall fall It was a day in Europa My regression recalls Hail to the mighty, the ritual begins Hail to Apollo, the cleanser of sins Hail to Europa, she always wins

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