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Horizon City Police report a large law enforcement presence near Maravillas and Desierto Bueno after a pursuit from El Paso ended in the area. Residents and motorists are urged to avoid the scene as updates follow.
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Nathan Hale was a schoolteacher from Connecticut and joined the Continental Army during the early days of the Revolutionary War. In the summer of 1776, as General George Washington’s forces faced increasing pressure from the British, Hale volunteered to gather intelligence on British troop movements and strategies. Knowing that this was an act of spying punishable by death, Hale travelled to behind enemy lines to British-controlled Long Island. Just over a week later the British captured New York City. A key account by a Loyalist shopkeeper claims that British Major Robert Rogers of the Queen’s Rangers recognised Hale in a tavern and managed to expose his allegiance to the Patriot cause. Hale was soon taken into custody and documents found in his possession, including his Yale diploma bearing his real name, left no doubt about his true identity and purpose. He was swiftly subjected to a trial by British authorities, found guilty of spying, and condemned to death as an illegal combatant. He was hanged on the morning of 22 September. News of the execution was passed to American Captain William Hull the next day. It is in his account that Hale’s final words are recorded, ‘I only regret that I have but one life to lose for my country.’ While there have been questions over the reliability of the account since Captain Hull was not an eyewitness to Hale’s speech, those words have since been celebrated as an embodiment of the spirit of sacrifice and commitment to the cause of American independence. Hale himself is considered an American hero, and continues to be commemorated across the nation.
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RUSSELL CO., Ala. (WRBL) – Names are being released of the two victims who died in a suspected murdered-suicide in Russell County. Russell County Sheriff’s Office deputies got the call at app…
A husband and wife are dead in what is believed to be a murder-suicide north of Gun Lake, police say.
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In TUNER, Academy Award-winning director Daniel Roher’s first narrative feature, Leo Woodall stars as a gifted young piano tuner whose heightened sense of hearing draws the attention of criminals, who see his talents as useful for opening safes as for tuning Steinways. With his once-promising musical career over, he works across New York with his mentor Harry Horowitz (Academy Award-winner Dustin Hoffman), encountering a range of characters, including composition student Ruthie (Havana Rose Liu), with whom he forges an unexpected connection. Niki’s safecracking work threatens his budding romance with Ruthie and pulls him into increasingly dangerous territory. Blending romance, drama, and the taut suspense of a heist thriller, TUNER also features performances from Tony Award-winner Tovah Feldshuh, Jean Reno, and Lior Raz.
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New York Attorney General Letitia James sued Trump, Trump Jr., Ivanka Trump, Eric Trump, and executives at the Trump Organization; the special master tasked with reviewing documents seized from Mar-a-
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Two people are dead following what is believed to be a murder suicide that took place on Wednesday evening in the Harrisburg Community east of Jasper.
In a homicide and arson case that rattled Burlington, police said Friday that a Wisconsin man shot John MaCurdy and Anna Downham inside a Carroll County home Monday morning
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The past few days have been devastating for the friends of 28-year-old Janeyri S. Urena De Paulino. Paulino was one of the three people found dead at a single-family home in along Constellation Road in Port St. Lucie late Saturday night, according to police.
Elizabeth Freeman was born into slavery in Claverack, New York in 1742. During the 1770s, she lived in the household of Colonel John Ashley of Sheffield, a prominent citizen who at that time also served as a judge of the Berkshire Court of Common Pleas. Colonel Ashley purchased Freeman from a Mr. Hogeboom when she was six months of age. Upon suffering physical abuse from Ashley’s wife, Freeman escaped her home and refused to return. She found a sympathetic ear with attorney Theodore Sedgwick, the father of the writer Catherine Sedgwick. Apparently, as she served dinner to her masters, she had heard them speaking of freedom—in this case freedom from England—and she applied the concepts of equality and freedom for all to herself. In 1781 Freeman, with the assistance of Sedgwick, initiated the case Brom and Bett v. Ashley that set a precedent for the abolition of slavery in Massachusetts. According to the Massachusetts Judicial Review, the 1781 Berkshire county case of Brom and Bett v. Ashley, often referred to as the Mum Bett or Elizabeth Freeman case, was unique because it occurred less than one year after the adoption of the Massachusetts Constitution and because, in contrast to prior freedom […]
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Trinity Church Wall Street is a growing and inclusive Episcopal parish, guided by our core values: faith, integrity, inclusiveness, compassion, social justice, and stewardship.
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DISCLAIMER: I don't own any of the material used in this video. No copyright infringement was intended in the making of this video. I make no money from this video, it is just a hobby. Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
Today we introduce a new contributor, retired Air Force judge advocate Colonel Pete Marksteiner, who offers a philosophical and practical perspective on the ongoing controversy about the military&#…
Police have confirmed that a major response at Heathrow this morning was triggered by an assault involving multiple people at Terminal 3, after several
The 1900 New York City, New York Race Riot began following an incident between Arthur J. Harris, a black man, and a white undercover police officer, Robert J. Thorpe, outside the apartment of Harris and his girlfriend May Enoch in the Tenderloin section of New York City. At 2:00 a.m. on August 13, Harris witnessed Thorpe grabbing Enoch, whom Thorpe believed to be a prostitute soliciting customers. Harris, not knowing that Thorpe was a police officer, attacked Thorpe and cut him with a knife. Both Harris and Enoch fled the scene. Harris left for his mother’s home in Washington D.C.and Enoch ran into her apartment where she was later arrested. Thorpe, who was also the son in-law of Acting Captain John Cooney of the local Twentieth Police Precinct, was taken to Roosevelt Hospital where he died the next day. The Tenderloin was a traditionally Irish section of New York that was becoming increasingly integrated by Southern black migrants looking for work in New York. Thorpe’s death pushed racial tensions between the two groups in the neighborhood to the edge. On August 15, the day before Thorpe’s funeral, a fight broke out near Thorpe’s family’s home between a white man, Thomas J. Healy, and a black man, Spencer Walters. […]
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Provided to YouTube by The Orchard Enterprises Alba · Fulltone · Amr Khaled Alba ℗ 2024 All Day I Dream Released on: 2024-05-17 Producer: Fulltone Music Publisher: Copyright Control Auto-generated by YouTube.
On June 14, 2012, Shantel Davis, a 23-year-old African-American woman, was fatally shot by New York City, New York Police Department (NYPD) officer Phil Atkins. She was unarmed, and her death occurred while the national discussion of police brutality was gaining publicity in the wake of similar killings. That debate led to the creation of the Black Lives Matter movement the following year. Just before her death, Davis ran several red lights and crashed the allegedly stolen car she was driving at an intersection in the East Flatbush section of Brooklyn. Two plainclothes police officers saw Davis driving erratically and pursued her vehicle. Once her car came to a stop after colliding with a minivan, the officers got out of their car and approached on foot. Davis opened her passenger side door, knocking one officer to the ground. She then got back into the driver’s seat. Believing that Davis was trying to drive away, and with the car moving backwards, Detective Phil Atkins reached into her car and tried to shift it into park. While they struggled for control, Atkins shot her once in the chest. When the officers asked her to exit the car, she stumbled out while bleeding profusely onto the pavement in front of a large […]
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मेष लव राशिफल (Aries Love Horoscope) आज आपका प्रेम जीवन बहुत ही गतिशील रहेगा। रोमांस की ओर सिंगल का आकर्षण और
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Reeds - Harry Carney, Russell Procope, Paul Gonsalves, Willie Smith, Jimmy Hamilton.... Trumpets - Ray Nance, Cootie Williams, Clark Terry, Willie Cook.... Trombones - Juan Tizol, Quentin Jackson, Britt Woodman.... Rhythm - Wendell Marshall (b), Louie Bellson (d), Duke Ellington (p).... ...................................................... Recorded - Snader Telescription, filmed Mar.14,1952. ...................................................... Why search for your favorite music in my channel? Because i'm always trying to name the musicians, place and date of the recordings! ............................................................ Please let me know if i have missed something. ............................................................ Make it easy on yourself.. check my playlists, or search my channel for your favorite artist/song..... ............................................................ Subscribe yourself to the channel to keep up with the latest uploads ............................................................ Have Fun!! ........................................................... I Will remove any video if asked too. ........................................................... And most of all !!! ........................................................... I hope that , trough these video's, i have inspired you to go and get the original recordings because there is nothing like the original!! So that's what i'm doing it for..... Go to your local recordstore, the internet or whatever, and get the original!! ........................................................... Enjoy !!! ............................................................ FAIR USE DISCLAIMER: I do not own copyright for this copyrighted artwork, but under Section 107 United States Copyright Law as noted by the United States Copyright Office (Copyright Act 1976), allowance is made for fair use for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. I state here in a good faith that I have made and uploaded here this copy of this copyrighted artwork completely for the purposes of teaching and research, that my action - i.e. my production of the copy of this copyrighted artwork and sharing of it here on Youtube in this particular case - is totally non-profit, and that I believe that my production of this copy of this copyrighted artwork and sharing of it here in Youtube in this particular case can only increase value of this copyrighted artwork and produce only positive effects for this copyrighted artwork in its potential market.
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Modern Electric Texas Blues 1994 Enjoy , my friends !!! *Disclaimer: All audio & visual parts in my videos are the sole property of their respective owners. The videos are purely for entertainment and recreational purposes. No Copyright infringement intended! All rights go to their rightful owners. I do not own the rights of the music. For your information, if a band or an artist wishes one or some of the songs/videos to be removed from my channel's upload list, it is advisable to come into contact with me by sending a personal message and I will delete it or them as soon as possible.
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Concorsi di salto ostacoli: eventi di salto ostacoli nazionali e internazionali gestita dalla Associazione Equieffe Equestrian Centre. Scopri il calendario.
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Jose Rivera, the spokesperson for the Grape Creek Volunteer Fire Department, has initiated a public discussion regarding the construction of an overpass for FM 2105 at the intersection of US 87 North.
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Provided to YouTube by Pias UK Limited Dance Your Life Away (Andrew Weatherall Remix) · Andrew Weatherall · audiobooks Dance Your Life Away ℗ 2018 Heavenly Recordings under exclusive license to [PIAS] Released on: 2018-10-03 Mixer: audiobooks Producer: audiobooks Music Publisher: Copyright Control Composer: audiobooks Lyricist: audiobooks Auto-generated by YouTube.
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Letture 2024: bilancio di un viaggio alla scoperta del mondo femminile, di Chiara Vicomario
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Andiamo alla scoperta della città francese di Carcassonne, un gioiello medievale dove il tempo sembra non scorrere: ecco le sue bellezze da visitare.
I attended a seminar many years ago given by a Ph.D. student who had spent years working on a particular type of childhood cancer. During the question-and-answer period, I raised my hand. I wanted to know why it was that children even got cancer when most cancers require decades of mutation accumulation. The student didn’t seem to understand my question, which I reformulated a couple of times before one of the professors in the audience turned to me and said, “It’s stochastic,” meaning it’s random, it can’t be predicted, and it’s just bad luck. Let’s just say that I remained unsatisfied. When adults get diagnosed with cancer, the question they often ask themselves is “why me?” But from a biological perspective, it’s not surprising. The way in which our cells divide requires so many moving parts that, once in a while, something is going to break down, leading to the uncontrolled cell growth characteristic of cancer. This breakdown takes decades. Yet, retinoblastoma, a tumour of the back of the eye that almost only affects children, usually gets diagnosed between the ages of one and two. How can cancer be a tortoise in adults but a hare in children? The cancer ballet Our bodies are made up of cells and these cells are not static. They will regularly duplicate their DNA content and split into two. This process, which is crucial to life, is very tightly regulated. It is called the cell cycle. You can think of it as a wonderfully choreographed ballet involving hundreds of dancers—proteins, in the case of the cell cycle—and they all have a precise time to enter the stage, fulfill their role, and return behind the curtain. Day in, day out, proteins inside our cells perform Swan Lake over and over again, always hitting their mark. But sometimes, an important dancer is sick or is simply missing, and the choreography goes awry, more Black Swan than Swan Lake. Over time, more and more dancers get sick and the whole production gets out of control. The troupe starts invading the seating area, recruiting members of the audience for their insubordinate dance, and the massive, incoherent ballet pours out of the theatre and disrupts city life. This is cancer. Proteins in cancer misbehave or simply disappear because the genes that produce them have been mutated. Exactly when those mutations happen has a direct influence on when someone develops cancer. In 1971, Alfred Knudson proposed a hypothesis for how mutations and cancer were linked. It is known as the two-hit hypothesis. For cancer to start, the prima ballerina has to be taken out of commission. But, of course, she has an understudy. We have two copies of most genes, one from our father and one from our mother. If one copy is rendered useless, we still have the other copy to make a functional protein. This is what Knudson zeroed in on. He hypothesized, quite correctly, that in cancer, a mutation arises that inactivates the first copy of that gene. Later, a second mutation needs to hit that other copy. When both the prima ballerina and her understudy have been quashed, the ballet starts to lose control. (Analogies inevitably break down. There is no one prima ballerina in our cells, but many prima ballerinas—proteins that play key roles—and different cancers will emerge from the mutation of different key ballerinas.) Knudson used retinoblastoma to make his point about his two-hit hypothesis. The gene RB1 codes for the protein RB1, which acts as a necessary brake pedal in the cell cycle. When one copy of RB1 is mutated and then, later, the second copy, the RB1 protein can no longer play its role and cells start to divide out of control. At this stage, we see a benign tumour called a retinoma. If more mutations start to happen to other important proteins, the child will develop retinoblastoma, an actual cancer of the retina. A key to understanding cancer is that sometimes that first hit does not happen during the patient’s lifetime: sometimes, they have already inherited it from one of their parents. They are thus predisposed to developing cancer, and if they do get cancer they will typically be diagnosed at a much earlier age. This is why a 60-year-old woman presenting to a doctor with breast cancer will be seen as “normal,” but a 25-year-old woman presenting with the same will arouse suspicions that she inherited an important mutation from a parent. This is the difference between sporadic cancers, where both hits need to happen during the patient’s lifetime and thus often take decades, and inherited cancers, where only one important hit needs to happen during the patient’s lifetime and thus cancer arises earlier. This model explains why over half of all cancers affect people older than 70 and why young adults with cancer will often be sent for genetic testing and counselling, because the mutation they inherited from a parent could further spread throughout the family. But it doesn’t explain why children develop cancer in the first place. That is because their tumours tend to be very different from adult cancers. Fewer mutations, fusion genes, and epigenetic alterations Even without an understanding of the underlying genetics, we can simply look at the cancers that typically affect adults and children and notice that they are not the same. Leukemias, which affect white blood cells, make up about a third of all cancers in children, but they are 12th in frequency when looking at all age groups. The most common malignant brain tumour in children is medulloblastoma, which affects the back of the brain, but it is rarely found in adults. For glioblastoma, the opposite is true: common in adults but rare in children. Adults typically get diagnosed with breast, prostate, lung, or colorectal cancer. Children get afflicted by astrocytomas, leukemias, and osteosarcomas. Clearly, something different is happening here. The first observation that comes out of the medical literature on pediatric cancers is that they have fewer mutations than adult tumours. In adults, the prima ballerina and her understudy are knocked out, and more and more ballet dancers subsequently stop doing their job. There is an accumulation of mutations in many genes, and that phenomenon both creates the cancer and helps it progress. In children, fewer mutations are needed to initiate cancer. While all cancers feature mutations in important genes, the cancer-causing mutations that happen in children tend to be seen in genes that control progression through the cell cycle. The RB1 gene is a perfect example. When absent, the cell cycle keeps going without regulation, with cells dividing and dividing and turning into tumours. We also see more fusion genes in pediatric cancers versus adult cancers. A fusion gene is when one half of a gene gets combined with one half of another gene, creating a new protein that did not exist before. It may not seem like much, but when the first gene has a very important role to play intermittently and the second gene acts as a license to do it all the time, we end up with an overactive gene that favours the uncontrolled division of cells. It’s like installing a rocket engine at the back of a car and snipping the brake line during the fitting. The part-car, part-rocket vehicle will cause havoc on the highway. Finally, childhood cancers differ from adult cancers not just genetically but also epigenetically. Genes make proteins but genes do not make proteins continually. Just like the cell cycle is tightly regulated, so is the production of proteins through gene expression. That process is known as epigenetic regulation, where “epigenetic” means “on top of the gene.” There are ways in which the genes are rendered inaccessible or silent, and it involves things like methylation and histones, and the genes coding for those very things are often mutated in childhood cancers. It means that gene expression is not as restrained as it should normally be, which leads to tumours forming faster. These answers are helpful but they are not enough for us to fully understand what distinguishes pediatric cancers from adult ones. All of these peculiarities seem to interact and when they happen in the wrong cell at the wrong time of development, cancer follows. With all of this talk of mutations driving cancer, you may be wondering how these mutations happen in the first place. Here too our understanding is incomplete. We know that certain behaviours in adults increase the risk of them developing cancer later in life, like smoking cigarettes and being exposed to ultraviolet radiation (such as the one found in sunlight) without protection. But children are too young for their behaviour to cause cancer at a young age. Certain viruses clearly cause cancer in adults, such as HPV resulting in cervical and anal cancer (among others). In children, some viruses like the Epstein-Barr virus have been shown to play a role in the development and progression of cancer, but our knowledge here is fragmentary. Much like in adults, roughly 10% of children with cancer are predisposed to it by inheriting a mutation from one of their parents. But as far as we know, everything else, as painful as it is to say, is stochastic. It is random, unpredictable, and just bad luck. Neither the parents nor the child is to blame. Every year, 400,000 children and teenagers develop cancer worldwide. More research is definitely needed to further elucidate exactly why this happens and what we can do to help prevent it. Take-home message: - The types of cancers that usually affect children are different than the types of cancers common in adults - Childhood cancers tend to require fewer mutations to develop; they often show fusion genes, in which parts of two different genes combine to create a protein that misbehaves; and they commonly show mutations in the molecules that regulate genes - As in adults, about one in ten children with cancer will have inherited a mutation from a parent that predisposes them to developing a tumour @CrackedScience